Grünenthal Limited
TOR Building
St Cloud Way
Maidenhead SL6 8BN
Phone: +44 (0)870 351 8960

For Medical Information, Reporting Safety and Quality Related Issues see here

... About us

We are an independent, family-owned company with headquarters in Aachen, Germany. We are present in 29 countries with affiliates in Europe, Latin America and the USA. Our products are sold in more than 100 countries and we employ around 4,700 employees worldwide.

... Company Overview

Although firmly rooted in Germany, today we are very much a growing global business.

... History

At Grünenthal, conducting our business responsibly is a core part of our company’s strategy and culture. As a global leader in pain management, Grünenthal aspires to create a positive impact on society – in our core business and beyond. We are guided by integrity, transparency and the highest ethical standards.

... Responsibility

Although firmly rooted in Germany, today we’re very much a growing global business, represented in 27 countries and maintaining production sites in five.

... Global Capabilities

We are dedicated to creating a better future for our patients, so getting involved with diverse initiatives that support this goal is vital.

... Initiatives

... Requests for Funding

Patients’ needs are at the heart of everything we do; using our passion for science, we develop long-lasting solutions that directly address these needs.

... Products

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Ationdo.

... Ationdo

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Nebido.

... Nebido

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Palexia.

... Palexia

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Qutenza.

... Qutenza

We are dedicated to creating a better future for our patients, Read the package leaflet information to find out more about Ralvo.

... Ralvo

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Tramacet.

... Tramacet

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Versatis.

... Versatis

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Vimovo .

... Vimovo

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Zydol.

... Zydol

We are dedicated to creating a better future for our patients, read the package leaflet information to find out more about Zomig.

... Zomig

Patients’ needs are at the heart of everything we do; using our passion for science, we develop long-lasting solutions that directly address these needs. Read the package leaflet information to find out more about our products.

... Reporting Safety and Quality Related complaints

Take warning signals seriously

Acute pain is the normal, predictable physiological response to an injurious (noxious) stimulus. It can be clearly located, and its intensity correlates with the stimulus.

In contrast to chronic pain, it is of limited duration and subsides on termination of the damage or healing. Acute pain has a warning and protective function: It indicates existing damage and prevents further damage by initiating avoidance reactions.

Pathophysiology

Activity of the Pain Sensors

Acute pain results from any condition that stimulates the body’s “pain sensors” (nociceptors), such as injuries, bleeds (haemorrhages), tumours, infections, and metabolic and endocrine problems. Acute pain usually occurs after surgery, physical injury or sports injuries.

Acute pain is caused by a pain stimulus that excites the pain receptors (nociceptors), which transmit stimuli to the spinal cord. The pain stimulus can then be diverted to the motor neurons, evoking a reflex response such as withdrawing a limb. Then the pain stimulus is transmitted to supra-spinal structures involved in pain processing and eventually reaches the brain, where it is perceived as pain. Supra-spinal reflexes also activate the heart and respiratory rate and induce the release of stress hormones.

Diagnosis

Assessment and Help

In acute pain, the underlying cause is often obvious, e.g. after surgery or an acute trauma. Many times, however, the exact underlying pathology is not clear and a diagnostic work-up is necessary. Key elements include:

Performance of a full physical examination
Assessment of pain location, severity, quality, onset and aggravating/relieving factors (for a rapid and simple assessment of the pain severity, pain scales can be used as a validated measurement tool)
Utilisation of specific diagnostic procedures such as X-rays or bone scans

... Click here for more information on pain scales for measuring pain

Diagnosis

Effective pain management requires an accurate assessment of pain.

... Explore

M-N/A-UK-03-24-0008 - March 2024